Hi, my name is
If you're going to do me 😉
Do me, safely.
This is a harm reduction guide with safety tips for psychedelics: LSD, psilocybin (shrooms), etc.
Psychedelics need to be treated with care.
And we'd like to tell you how.
Did you know? There's a scientific paper that gives guidelines for safe use of psychedelics. If you want to be really prepared, we encourage you to read the whole paper.
1. Avoid psychedelics if you don't pass the risk factors
Of 1200 LSD or mescaline research participants, only one person had a psychotic episode lasting more than 48 hours.
They had a schizophrenic twin. 
This is the list that researchers recommend screening psychedelic participants by:
2. Have a sober guide who knows how to "Trip Safe"
Have a 100% trusted sober guide present in the same location during the entire session. The guide should have good people skills and compassion, and the participant should feel comfortable expressing all aspects of themselves (especially sorrow, embarrassments, etc) with the guide, if they come up. Researchers recommend against having only a guide of the opposite gender to the participant. 
3. Have a safe environment
100% familiar (participant has been in the space at least once before for some time) and safe environment, with no sharp objects or utensils, windows that could be jumped out of, and no telephones if possible. 
4. If you're trip sitting and your friend experiences fear or anxiety
Encourage participants to mentally surrender to the experience if they face any challenging experiences. The guide should not try to talk them down to reality, but they can encourage them to mentally surrender and remind them that they will return to normal consciousness in ‘a few minutes’ or ‘a few hours’. 
See this guide for more information.
If distress can’t be managed with reassurance alone: oral 10mg Valium (diazepam) is recommended by researchers.  Xanax is less preferable as it takes longer to onset , but if used 0.5mg Xanax is equivalent in effect to 10mg Valium .
If a family member of mine was doing psychedelics soon, here's what I'd tell them.
"The 10 Step Psychedelic Safety Guide"
Prep, Step 0: Don't use psychedelics if these apply to you
Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008). "The Pharmacology of Lysergic Acid Diethylamide: a Review". CNS Neuroscience & Therapeutics. 14 (4): 295–314. doi:10.1111/j.1755-5949.2008.00059.x. PMID 19040555.
Murray RM, Paparelli A, Morrison PD, Marconi A, Di Forti M (October 2013), "What can we learn about schizophrenia from studying the human model, drug-induced psychosis?", American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162 (7, Special Issue: Identifying the Origins of Mental Illness: A Festschrift in Honor of Ming T. Tsuang): 661–670, doi:10.1002/ajmg.b.32177
Prep, Step 1: If you're doing LSD, be careful to get real LSD.
This is less of an issue with shrooms but still something to be aware of.
If a family member was doing LSD, I would tell them not to get it from a dealer.
"Firstly, it's illegal, so you shouldn't buy it and there are risks. But if you're going to buy it, do so from the dark net markets instead of a dealer, and read reviews to increase your confidence and pick a reputable vendor. You should test it as well, but realistically, Mr/Mrs family member, I expect if you order from a reputable vendor, you'll end up with safe/mostly pure product."
Thank you to the DNM avengers, the harm reduction community appreciates you.
Anecdotally it seems that LSD purchased online is much likely to be safer than LSD purchased offline. If you take this route, look for guides and resources on websites like Reddit so that you know how to get the safest substances.
Alternatively, do Shrooms instead of LSD, as your risk of getting dangerous fake product goes to near zero.
Prep, Step 2: If you're doing LSD, order a test kit so it arrives in time
You should test even if you're getting it from a dark net vendor with good reviews and high trust. Just like you also should never download music illegally, you should never procrastinate, and so on. I'm being realistic. If I was talking to a family member, I wouldn't beg them to test it if I knew they were getting it from a good vendor on the dark net market.
This is less of an issue with shrooms but still something to be aware of.
If a family member was getting LSD from anywhere other than a high trust dark net market vendor, I would beg them to order a test kit. Real LSD, relative to other drugs, is pretty safe.
Good LSD test kits:
Think swallowing the tab means you don't have to test it? Unfortunately this isn't guaranteed. (The myth goes "if you swallow a tab of acid then if it's fake it won't work but if it's acid it will). Swallowing a tab for protection is definitely better than nothing and can only help, but our current understanding is that it's not a guarantee
Not convinced you should order a test kit? Read this.
Prep, Step 3: If you're tripping, do it on a Friday or Saturday.
We strongly recommend treating psychedelics as a 2 day experience. >8 hrs sleep the night before, then the big day, then >8 hrs sleep that night, then take the next day for rest/recovery.
A rest day is beneficial for both mental and physical health.
This likely means tripping on a Friday or Saturday if you work Monday-Friday.
Prep, Step 4: If you're tripping, consider doing it at home instead of at a venue
Why would I recommend this to a family member?
Especially before someone has experience (say 3-4 trips) I believe it's a good idea to trip in environments you know well. This way less unexpected things happen. Unexpected things can be hard to deal with on psychedelics.
Prep, Step 5: Be smart with dosage
Psychedelic doses are not linear.
150ug of LSD is more than 1.5x as strong as 100ug of LSD
Another point to consider: LSD from dark net markets is often stronger than "street LSD". So each time you get LSD from a new source, you should do a small-ish dose so that you know how strong the "batch/source" is.
Different mushrooms have different potencies.
As a general rule:
• Threshold: .25 g; 1/100oz
• Light: .25 - 1 g; 1/100-1/28oz
• Common: 1 - 2.5 g; 1/28-1/10oz
• Strong: 2.5 - 5 g; 1/10-1/6oz
• Heavy: 5 + g; 1/6oz+
Researchers found that ~3.2 g mushrooms has about a 6x lower rate of "extreme" fear or anxiety compared to 4.8 g. 
(Or more precisely, 20 mg psilocybin per 70 kg instead of 30 mg psilocybin per 70 kg.)
Anecdotally psychedelic dosage does not seem to vary much by weight
Prep, Step 6: Pro-trip-tips
(I would advise a family member to read this list carefully and follow the recommendations, especially if they had done psychedelics less than ~5 times)
Xanax or Valium can be used to smooth out a trip
It can be more long term beneficial to "go into the discomfort" and learn from your rough experiences, but this is useful information still.
Medical literature advises "a 10 mg oral dose of diazepam (valium)". Researchers recommend valium instead of Xanax if possible, but if not possible, then 0.5 mg xanax is equivalent to 10 mg valium.
Best music on LSD
Prep, Step 7: Trip-sitter
A trip sitter is recommended if you're not experienced at a certain level of dosage.
If a family member had done 100ug 3-4 times, and had another 100ug from the same batch (so they knew it was likely the same strength), then I would say they would probably be fine by themselves.
If that same family member was going to do 175ug, and this was going to be their highest dosage so far, I would strongly encourage them or perhaps even mandate that they organized a trip sitter.
How to get a trip sitter? Tell your friend that you appreciate them, and think very highly of them, and trust them, and would feel comforted and good if they read the "Trip Sitter Preparation" section on TripSafe and then tripsat you.
The Aftermath, Step 9: Take a rest day, get sleep. Then wait until you've completely re-integrated the trip into your normal life before tripping again.
It is recommended to wait at least until you have completely reintegrated the previous trip into your life before tripping again.
Evangelism, Step 10: 😛 If after tripping you feel "the world would be better if more people did psychedelics at least once" check out these things
Strongly recommend buying "The Psychedelic Explorer's Guide". If you aren't convinced, listen to this podcast episode first: Tim Ferriss Show: The Psychedelic Explorer's Guide
This is also good: Tim Ferriss Show: Are Psychedelic Drugs the Next Medical Breakthrough? (the headline is optimized for clicks, but the content is awesome)
After doing psychedelics, you may find yourself wanting to attend burning man... Or perhaps you tried psychedelics at burning man. This is a better version of the burning man shopping checklist: BurnerList.org
Donate to Zendo
What is Zendo? Zendo provides Psychedelic First Aid for Festivals & Events. Read more.
Clinical guidelines for safety:
Research on whether psychedelics lead to mental health problems or not:
Hendricks, P. S., Thorne, C. B., Clark, C. B., Coombs, D. W., & Johnson, M. W. (2015, March 13). Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. Journal of Psychopharmacology, 29(3), 280-288. doi:10.1177/0269881114565653
Johansen, P., & Krebs, T. S. (2015, March 01). Psychedelics not linked to mental health problems or suicidal behavior: A population study. Journal of Psychopharmacology, 29(3), 270-279. doi:10.1177/0269881114568039
Get drug policy to move forward and become more sensible
The single most effective thing you can do to move drug policy forward is to be out and proud about your own use.
The best example from history: gay marriage approval. Initially, most people didn't know other gay couples, and approval was low. Then as gay people started to come out, more and more people knew people who they were already friends with that they now knew were gay. When you have a gay friend, it's much harder to oppose gay marriage. And so eventually, the approval started shifting, and then the policy began to follow.
The same will happen with psychedelics.
Tweet with #PsychedelicsBecause (doesn't auto tweet, it lets you edit before sending)
Share Psychedelic Society's "Intro to Psychedelics" on Facebook (doesn't auto post, it lets you edit before sending, and you can choose to only share with specific people/groups)
Share TripSafe.org on Facebook (doesn't auto post, it lets you edit before sending, and you can choose to only share with specific people/groups)
My friend is having a rough trip
The purpose of sitting with someone in crisis is not to reduce effects, but to create and maintain a safe place where the individual can play out the process without coming into contact with themselves or others.
Everything is Fine with Me: Make it clear that the whole world may be falling apart for them, but everything is OK with you.
Also, if you're having a bad trip, no you won't die! Things can seem much worse during the trip. Afterwards, they will realize, of course I/they weren't going to die, but during the trip some aspects of reality can disappear, so remember to be reassuring.
Though if they didn't ask if they are going to die, don't go saying, “don't worry, you're not going to die”... That won't be very helpful! Instead, remember, make it clear that no matter what is going on with them, everything is OK with you, you aren't scared for them, etc. If you're really scared for them and show it, they will likely get unnecessarily worried.
If you have a blanket: 'the most comforting thing that some people reported helped them during the most acute experiences is having a blanked wrapped around them.'
I am having a rough trip
Calming videos for if you are having a rough trip
Prep checklist: Your friend is tripping soon
Want to know how to be an awesome trip sitter?
You're a great friend for doing this!
Do the following three things.
And then read the 'my friend is having a rough trip' section
If you want to be super thorough, read https://drugs-forum.com/forum/showwiki.php?title=The_psychedelic_crisis:_bad_trip and the Zendo Project Trip Sitter Guide
I cannot emphasize enough how valuable this 30 minute time investment is. Watch the videos with friends if you want, and that way it's just an excuse to watch videos with people.
http://psychsitter.com/download-manual/ (long but good)
What are some psychedelic medical research studies currently recruiting participants?
Interested in microdosing? You should check out this!
Where can I learn more about using psychedelics for psychotherapy?
If you wish to use psychedelics as a tool to assist psychotherapy, here are some links to check out.
What is TripSafe?
TripSafe provides safety tips and advice to help people who are going to do psychedelics like shrooms or LSD have the best and safest time possible.
Where can I learn about entheogenic trips?
Entheogenic roughly means drawing yourself closer to spirituality, or the god within.
See the book The Psychedelic Explorer's Guide for a guide on how to perform such an experience.
It requires two people, one sitter and one tripper.
What are psychedelics?
What does tripping do? Will I see elephants that don't exist?
See here for an extremely accurate representation of what you might see.
Other great resources to understand the basics:
TripSafe is a psychedelic harm reduction website.
Do not consume any drugs without consulting a medical professional. This is for informational purposes only.
How safe are LSD and Shrooms relative to other drugs, like Cannabis and Tobacco?
Nutt, D. J., King, L. A., & Phillips, L. D. (2010, November 01). Drug harms in the UK: A multicriteria decision analysis. The Lancet, 376(9752), 1558-1565. doi:10.1016/s0140-6736(10)61462-6
Blue bar = harm to user, independent on the popularity of the drug
Red bar = harm to society, depends on popularity of the drug
"Finally, we should note that a low score in our assessment does not mean the drug is not harmful, since all drugs can be harmful under specific circumstances." Be safe.
View paper: 
A BOOK YOU SHOULD BUY
If you're at all into psychedelics. Note added May 4 2016
UX + web designer or good editor/storyteller?
Volunteer to help out
We'd love someone to help turn this: TripSafe comprehensive guide
Into a much more readable simplified version - both content wise, and visual/design wise. Right now that page is comprehensive, but it's far too much to expect most people to read. We'd like it to be simple enough that anyone considering psychedelics can read it.
Making websites or infographics that look pleasant
Writing content that is engaging and simple (e.g. you've read Nobody Wants to Read Your Sh*t by Pressfield/Coyne)
TripSafe helps over 150,000 people per year, so your work will be valued.
Email [email protected] if you may be interested in volunteering. No worries if you've never volunteered for anything before, we will make it simple :-)